Dariane C, Peycelon M, Lallemant P, Forin V, Audry G
Service de chirurgie viscérale pédiatrique et néonatale, hôpital Trousseau, hôpitaux universitaires Est Parisien, AP-HP, 26, avenue du Docteur-Arnold-Netter, 75571 Paris cedex 12, France.
Service de chirurgie viscérale pédiatrique et néonatale, hôpital Trousseau, hôpitaux universitaires Est Parisien, AP-HP, 26, avenue du Docteur-Arnold-Netter, 75571 Paris cedex 12, France; UFR de médecine Pierre-et-Marie-Curie, UPMC université Paris 06, 75005 Paris, France; Inserm UMRS_933, service de cytogénétique et d'embryologie médicales, hôpital Trousseau, hôpitaux universitaires Est Parisien, AP-HP, 75571 Paris, France.
Prog Urol. 2014 Jan;24(1):39-45. doi: 10.1016/j.purol.2013.05.001. Epub 2013 Jun 12.
The urological management of urinary incontinence in neurogenic bladder due to spinal cord lesions in children is intended to achieve social continence while preserving the upper urinary tract, combining clean intermittent catheterization with anticholinergic agents. The objective of this study was to report the results on continence of endoscopic management of bladder and/or sphincter of children with failure or intolerance to first intention therapy.
Of the 364 children followed for neurologic bladder in our institution, 22 required endoscopic management between 2000 and 2012. Urinary incontinence was related to detrusor overactivity in 16 children and sphincter deficiency in 13 children, requiring one or several intradetrusor injections of botulinium toxin-A (BTA) and/or dextranomer/hyaluronic acid (Dx/Ha) injection in the bladder neck. Continence was reassessed between six and eight weeks after the last injection using the Schulte-Baukloh score.
At the end of the mean follow-up of four years, 16 children received 54 injections of BTA and 13 children had 24 injections of Dx/Ha. Social continence, defined as a score between 0 and 1, was acquired quickly after injection of BTA and required to repeat the injections every 8.7 months (6-12) with a very low morbidity. After the first injection of Dx/Ha, 69% of the children improved significantly their incontinence score (from 1 to 0 or from 2 or 3 to 1) with better results for girls.
An appropriate endoscopic management has enabled an improvement of the continence of two-thirds of children who fail first intention treatment for their neurogenic bladder. This is an alternative to delay or avoid major surgery.
儿童脊髓损伤所致神经源性膀胱尿失禁的泌尿外科管理旨在实现社会控尿,同时保护上尿路,将清洁间歇性导尿与抗胆碱能药物相结合。本研究的目的是报告对初始治疗失败或不耐受的儿童膀胱和/或括约肌进行内镜治疗的控尿结果。
在我们机构随访的364例神经源性膀胱患儿中,2000年至2012年间有22例需要内镜治疗。16例患儿尿失禁与逼尿肌过度活动有关,13例患儿与括约肌功能不全有关,需要在逼尿肌内注射一次或多次A型肉毒杆菌毒素(BTA)和/或在膀胱颈注射葡聚糖/透明质酸(Dx/Ha)。在最后一次注射后6至8周,使用舒尔特 - 鲍克洛评分重新评估控尿情况。
在平均4年的随访结束时,16例患儿接受了54次BTA注射,13例患儿接受了24次Dx/Ha注射。定义为0至1分的社会控尿在注射BTA后很快实现,需要每8.7个月(6 - 12个月)重复注射,发病率极低。首次注射Dx/Ha后,69%的患儿失禁评分显著改善(从1分改善至0分或从2分或3分改善至1分),女孩的效果更好。
适当的内镜治疗使三分之二初始治疗失败的神经源性膀胱患儿的控尿情况得到改善。这是延迟或避免大型手术的一种替代方法。