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111铟或177镥标记的生长抑素类似物单瓶即用型制剂的应用。

Application of single-vial ready-for-use formulation of 111In- or 177Lu-labelled somatostatin analogs.

作者信息

de Blois Erik, Chan Ho Sze, de Zanger Rory, Konijnenberg Mark, Breeman Wouter A P

机构信息

Erasmus MC Rotterdam, Department of Nuclear Medicine, 's Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands.

Erasmus MC Rotterdam, Department of Nuclear Medicine, 's Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands.

出版信息

Appl Radiat Isot. 2014 Feb;85:28-33. doi: 10.1016/j.apradiso.2013.10.023. Epub 2013 Dec 10.

Abstract

For the sake of safety it would be desirable to store and transport the ready-for-use liquid formulation (diagnostics and therapeutics) of radiolabelled peptides. The use of ethanol, in combination with a mixture of gentisic- and ascorbic acid, has superior effects on stabilizing radiolabelled somatostatin analogs. As a consequence, (111)In- and (177)Lu-labelled somatostatin analogs can be stored and transported in a single-vial ready-for-use liquid formulation up to 7 days after radiolabelling.

摘要

为了安全起见,储存和运输放射性标记肽的即用型液体制剂(诊断和治疗剂)是很有必要的。乙醇与龙胆酸和抗坏血酸的混合物结合使用,对稳定放射性标记的生长抑素类似物具有更好的效果。因此,放射性标记后的(111)铟和(177)镥标记的生长抑素类似物可以在单瓶即用型液体制剂中储存和运输长达7天。

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