Shan Shi-Jun, Guo Ying
*Ackerman Academy of Dermatopathology, New York, NY; and †Department of Dermatology, Affiliated Hospital of Tianjin Academy of Traditional Chinese Medicine, Tianjin, China.
Am J Dermatopathol. 2014 Jun;36(6):510-2. doi: 10.1097/DAD.0000000000000036.
Sclerosing lipogranuloma is a granulomatous reaction to the injection of a high-viscosity fluid in the tissues for the cosmetic purpose of improving body contour; lesions on the extremities and buttocks are commonly the results of injections of therapeutic agents in oily vehicles. Exenatide, once-weekly injection, is a therapeutic method for patients with type 2 diabetes. Here, we describe a case of exenatide once weekly induced eosinophilic sclerosing lipogranuloma at the injection site of a 62-year-old patient. To the best of our knowledge, the histopathologic features of this adverse event have not been reported in the medical literature.
硬化性脂肪肉芽肿是机体为改善身体轮廓进行美容目的而在组织中注射高粘性液体所引发的一种肉芽肿反应；四肢和臀部的病变通常是油性载体中注射治疗药物所致。艾塞那肽每周一次注射是2型糖尿病患者的一种治疗方法。在此，我们描述了一例62岁患者在艾塞那肽每周一次注射部位发生嗜酸性硬化性脂肪肉芽肿的病例。据我们所知，该不良事件的组织病理学特征在医学文献中尚未见报道。
