树突状细胞稳态和功能的遗传剖析：基于细胞类型特异性基因敲除的研究进展。
Genetic dissection of dendritic cell homeostasis and function: lessons from cell type-specific gene ablation.
机构信息
Department of Immunology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN, 38105-3678, USA.
出版信息
Cell Mol Life Sci. 2014 May;71(10):1893-906. doi: 10.1007/s00018-013-1534-7. Epub 2013 Dec 24.
Abstract
Dendritic cells (DCs) are a heterogeneous cell population of great importance in the immune system. The emergence of new genetic technology utilizing the CD11c promoter and Cre recombinase has facilitated the dissection of functional significance and molecular regulation of DCs in immune responses and homeostasis in vivo. For the first time, this strategy allows observation of the effects of DC-specific gene deletion on immune system function in an intact organism. In this review, we present the latest findings from studies using the Cre recombinase system for cell type-specific deletion of key molecules that mediate DC homeostasis and function. Our focus is on the molecular pathways that orchestrate DC life span, migration, antigen presentation, pattern recognition, and cytokine production and signaling.
摘要
树突状细胞 (DCs) 是免疫系统中具有重要意义的异质性细胞群体。利用 CD11c 启动子和 Cre 重组酶的新技术的出现，促进了 DC 在体内免疫反应和稳态中的功能意义和分子调控的剖析。首次，该策略允许在完整的生物体中观察 DC 特异性基因缺失对免疫系统功能的影响。在这篇综述中，我们介绍了使用 Cre 重组酶系统进行关键分子的细胞类型特异性缺失的最新研究结果，这些分子介导 DC 的稳态和功能。我们的重点是协调 DC 寿命、迁移、抗原呈递、模式识别以及细胞因子产生和信号转导的分子途径。
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