完全性葡萄胎妊娠中异常低的人绒毛膜促性腺激素：钩状效应。
Abnormally low hCG in a complete hydatidiform molar pregnancy: The hook effect.
作者信息
Nodler James L, Kim Kenneth H, Alvarez Ronald D
机构信息
Department of Obstetrics and Gynecology, The University of Alabama at Birmingham, AL, USA.
Division of Gynecologic Oncology, The University of Alabama at Birmingham, AL, USA.
出版信息
Gynecol Oncol Case Rep. 2011 Oct 20;1(1):6-7. doi: 10.1016/j.gynor.2011.10.003. eCollection 2011.
Abstract
► The hook effect occurs with extremely high levels of hCG, saturating detection antibodies, leading to falsely low laboratory results. ► In the literature, descriptions of the hook effect are rare in cases of gestational trophoblastic diseases. ► If unrecognized, this can lead to delayed therapy or mismanagement of care.
摘要
► 钩状效应发生在人绒毛膜促性腺激素（hCG）水平极高时，使检测抗体饱和，导致实验室结果出现假性低值。
► 在文献中，妊娠滋养细胞疾病病例中钩状效应的描述很少见。
► 如果未被识别，这可能导致治疗延迟或护理管理不当。
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本文引用的文献
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Falsely decreased human chorionic gonadotropin (hCG) results due to increased concentrations of the free beta subunit and the beta core fragment in quantitative hCG assays.由于定量 hCG 检测中游离β亚基和β核心片段浓度增加，导致人绒毛膜促性腺激素（hCG）结果假性降低。
Clin Chem. 2010 Dec;56(12):1839-44. doi: 10.1373/clinchem.2010.143479. Epub 2010 Oct 7.
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The quagmire of hCG and hCG testing in gynecologic oncology.妇科肿瘤学中hCG及hCG检测的困境
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Current management of gestational trophoblastic diseases.妊娠滋养细胞疾病的当前管理
Gynecol Oncol. 2009 Mar;112(3):654-62. doi: 10.1016/j.ygyno.2008.09.005. Epub 2008 Oct 12.
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Immunoassay of human chorionic gonadotropin, its free subunits, and metabolites.人绒毛膜促性腺激素及其游离亚基和代谢产物的免疫测定。
Clin Chem. 1997 Dec;43(12):2233-43.
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