衰老对胆碱磷酸甘油酯轴突运输速率的影响。

Effect of aging on the rate of axonal transport of choline-phosphoglycerides.

作者信息

Brunetti M, Miscena A, Salviati A, Gaiti A

出版信息

Neurochem Res. 1987 Jan;12(1):61-5. doi: 10.1007/BF00971365.

Abstract

The anterograde axonal transport of choline-phosphoglycerides was studied in sciatic nerve motoneurons of adult (3-month-old) and aged (24-month-old) rats. After the spinal cord injection of [2-3H]glycerol, choline-phosphoglycerides; the major phospholipid class was transported along the nerve. The axonal transport rate was determined by plotting the distance covered by the front of transported radioactivity as a function of the time employed. In aged animals the rate of the choline-phosphoglyceride anterograde axonal transport was about 68% lower than that of adults; furthermore, the rate slowed down along the nerve in the proximal-distal direction. This altered axonal transport mechanism might contribute to the degenerative processes observed in distal regions of peripheral nerve fibers of aged animals.

摘要

研究了成年（3个月大）和老年（24个月大）大鼠坐骨神经运动神经元中胆碱磷酸甘油酯的顺行轴突运输。在脊髓注射[2-³H]甘油后，胆碱磷酸甘油酯（主要的磷脂类别）沿神经运输。通过绘制运输放射性前沿所覆盖的距离与所用时间的函数关系来确定轴突运输速率。在老年动物中，胆碱磷酸甘油酯顺行轴突运输的速率比成年动物低约68%；此外，该速率沿神经在近端到远端方向逐渐减慢。这种改变的轴突运输机制可能导致在老年动物外周神经纤维远端区域观察到的退行性过程。