Salari A, Shafaghi A, Ofoghi M, Saeidinia A, Mansour-Ghanaei F
Department of Cardiology, Guilan University of Medical Sciences (GUMS), Rasht, Iran.
Division of Gastroenterology & Hepatology, Department of Gastroenterology, Gastrointestinal and Liver Diseases Research Center (GLDRC), Guilan University of Medical Sciences (GUMS), Razi Hospital, Sardar-Jangal Avenue, Rasht, Iran.
Int J Hepatol. 2013;2013:892876. doi: 10.1155/2013/892876. Epub 2013 Nov 26.
Background. In this study, we evaluated the association between diastolic dysfunction severity and severity of cirrhosis in nonalcoholic cirrhotic patients. Methods. This cross-sectional study was conducted on all nonalcoholic cirrhotic patients who were admitted in Rasht Razi hospital the Cancer of Guilan Province, north of Iran, from January 2011 to March 2012. Severity of cirrhosis was evaluated by Child-Pugh score. A 12-lead surface ECG and echocardiographic studies were performed. We used a HDI 3000 (Philips ATL, Bothell, WA, USA) equipped with 2 to 4 MHz probes. Diastolic function was determined by an expert cardiac sonographer. Data were analyzed by SPSS for win (version16). A P value less than 0.05 was considered significant. Results. Sixty-tree percent of patients were male. The mean age of patients was 52.78 ± 15.2 years. 22%, 38%, and 40% of patients were considered as child class A, B, and C, respectively. There was a significant relation between diastolic dysfunction and disease duration (P = 0.001), female gender (P = 0.004), age > 60 years (P = 0.045), and severity of cirrhosis (P = 0.048). On multivariate analysis, decreased E/A ratio (P = 0.03) and disease duration (P = 0.02) showed an independent significant relation. Conclusion. According to the relation between severity of cirrhosis and diastolic dysfunction, we recommend cardiac assessment in all child B and C cirrhotic patients.
背景。在本研究中，我们评估了非酒精性肝硬化患者舒张功能障碍严重程度与肝硬化严重程度之间的关联。方法。本横断面研究对2011年1月至2012年3月在伊朗北部吉兰省拉什特·拉齐医院收治的所有非酒精性肝硬化患者进行。采用Child-Pugh评分评估肝硬化的严重程度。进行了12导联体表心电图和超声心动图检查。我们使用配备2至4 MHz探头的HDI 3000（飞利浦ATL，美国华盛顿州博塞尔）。舒张功能由专业心脏超声检查人员测定。数据采用SPSS for win（版本16）进行分析。P值小于0.05被认为具有统计学意义。结果。63%的患者为男性。患者的平均年龄为52.78±15.2岁。分别有22%、38%和40%的患者被归类为Child A、B和C级。舒张功能障碍与病程（P = 0.001）、女性性别（P = 0.004）、年龄>60岁（P = 0.045）以及肝硬化严重程度（P = 0.048）之间存在显著关系。多因素分析显示，E/A比值降低（P = 0.03）和病程（P = 0.02）显示出独立的显著关系。结论。根据肝硬化严重程度与舒张功能障碍之间的关系，我们建议对所有Child B和C级肝硬化患者进行心脏评估。
