Ronner P
Ann N Y Acad Sci. 1986;488:341-55. doi: 10.1111/j.1749-6632.1986.tb46570.x.
The sodium dependence of insulin release was studied with the in vitro perfused principal islet of channel catfish. When extracellular sodium was replaced with choline, glucose-induced insulin release and glucose enhancement of arginine-induced insulin release were selectively abolished. Lowering the extracellular pH from 7.6 to 7.1 had a similar selective effect on glucose-induced insulin release. It is suggested that the Na:H antiport is responsible for the sodium dependence of insulin release and that a lowered cytosolic pH preferentially inhibits the glucose sensing mechanism.
利用体外灌注的斑点叉尾鮰主胰岛研究了胰岛素释放对钠的依赖性。当用胆碱替代细胞外钠时，葡萄糖诱导的胰岛素释放以及葡萄糖对精氨酸诱导的胰岛素释放的增强作用被选择性消除。将细胞外pH从7.6降至7.1对葡萄糖诱导的胰岛素释放有类似的选择性作用。研究表明，Na:H反向转运体负责胰岛素释放对钠的依赖性，并且胞质pH降低会优先抑制葡萄糖传感机制。
