Department of Pediatrics (M.A.B.V., G.N., C.B.M.K., S.M., E.L.T.v.d.A.), Erasmus Medical Center (MC), Sophia Children's Hospital, 3000 CB Rotterdam, The Netherlands; Academic Medical Center Medical Research BV (M.A.B.V.), Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands; Department of Internal Medicine (G.N., J.W.K., E.F.C.v.R.), Division of Endocrinology, Erasmus MC, 's Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands; Department of Pediatrics (M.H.T.M.J.), Sint Franciscus Gasthuis, Kleiweg 500, 3045 PM Rotterdam, The Netherlands; Obesity Center CGG, Erasmus MC and Sint Franciscus Gasthuis (M.A.B.V., G.N., M.H.T.M.J., C.B.M.K., S.M., J.W.K., E.F.C.v.R., E.L.T.v.d.A.), Rotterdam, 's Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands.
J Clin Endocrinol Metab. 2014 Jan;99(1):285-90. doi: 10.1210/jc.2013-2924. Epub 2014 Jan 1.
Pathologically increased cortisol exposure induces obesity, but it is not known whether relatively high cortisol within the physiological range is related to childhood obesity.
The aim of the study was to compare hair cortisol concentrations between obese and normal-weight children.
We performed an observational case-control study.
Twenty obese children (body mass index-SD score [BMI-SDS]>2.3) and 20 age- and sex-matched normal-weight children (BMI-SDS<1.1) aged 8-12 years were recruited.
Scalp hair samples from the posterior vertex were collected, and hair cortisol concentrations were measured using ELISA. Body weight, height, and waist circumference were measured. From the obese children, additional data on blood pressure and blood lipid concentrations were collected.
In both groups, five boys and 15 girls were included; their mean age was 10.8±1.3 vs 10.8±1.2 years (obese vs normal weight; not significant). Body weight, BMI, BMI-SDS, and waist circumference were higher in the obese children compared with the normal-weight children (69.8±17.2 vs 35.5±7.2 kg; 29.6±4.9 vs 16.4±1.6 kg/m2; 3.4±0.5 vs -0.2±0.8 SDS; 94±13 vs 62±6 cm; P<.001 all). Hair cortisol concentration was higher in obese than normal-weight children (median [interquartile range], 25 [17, 32] vs 17 [13, 21] pg/mg; P<.05).
Hair cortisol concentration, a measure for long-term cortisol exposure, was higher in obese children than normal-weight children. This suggests long-term activation of the hypothalamus-pituitary-adrenal axis in obese children and may provide a novel target for treatment of obesity in children.
病理上皮质醇暴露增加会导致肥胖，但目前尚不清楚生理范围内相对较高的皮质醇是否与儿童肥胖有关。
本研究旨在比较肥胖儿童和正常体重儿童的头发皮质醇浓度。
我们进行了一项观察性病例对照研究。
招募了 20 名肥胖儿童（体重指数标准差评分[BMI-SDS] > 2.3）和 20 名年龄和性别匹配的正常体重儿童（BMI-SDS < 1.1），年龄 8-12 岁。
采集后顶点头皮毛发样本，采用 ELISA 法测定头发皮质醇浓度。测量体重、身高和腰围。从肥胖儿童中还收集了血压和血脂浓度的额外数据。
两组均纳入 5 名男童和 15 名女童；平均年龄分别为 10.8±1.3 岁和 10.8±1.2 岁（肥胖组与正常体重组；无显著差异）。与正常体重儿童相比，肥胖儿童的体重、BMI、BMI-SDS 和腰围均较高（69.8±17.2 比 35.5±7.2 kg；29.6±4.9 比 16.4±1.6 kg/m2；3.4±0.5 比-0.2±0.8 SDS；94±13 比 62±6 cm；P<.001 均）。肥胖儿童的头发皮质醇浓度高于正常体重儿童（中位数[四分位数范围]，25 [17，32] 比 17 [13，21] pg/mg；P<.05）。
头发皮质醇浓度是长期皮质醇暴露的衡量指标，肥胖儿童的头发皮质醇浓度高于正常体重儿童。这表明肥胖儿童的下丘脑-垂体-肾上腺轴长期激活，这可能为儿童肥胖的治疗提供新的靶点。
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