Department of Diabetic Complications, Diabetes Research Center, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan.
Biosci Trends. 2013 Dec;7(6):276-83.
Leukocyte cell-derived chemotaxin 2 (LECT2) is a signaling molecule expressed in the liver and regulated by Wnt/β-catenin pathways implicated in hepatic metabolism. However, the clinical relevance of LECT2 in obesity and fatty liver is unknown. The objective of this study was to determine whether serum LECT2 levels are affected by of obesity and fatty liver. A cross sectional study comprising 231 Japanese adult subjects were tested for LECT2 using a highly sensitive assay. We evaluated the associations between LECT2 and the anthropometric or clinical markers of obesity and fatty liver. The mean serum LECT2 levels were 43.5 ± 13.6 ng/mL. LECT2 positively correlated with all the anthropometric measures of obesity: body mass index, waist circumference, waist-to-hip ratio, and waist-to-height ratio (W/Ht). Multiple regression analysis revealed that LECT2 is independently related to γ-glutamyl transpeptidase (γ-GTP), triglyceride, and age in males, whereas in females it was related to the homeostasis model assessment ratio, blood urea nitrogen, high-density lipoprotein cholesterol, and γ-GTP. Receiver operating characteristics curve analyses revealed that LECT2 correlated with obesity [area under the curve (AUC) 0.655, 95% confidence interval (CI) = 0.551-0.758, p = 0.002 in males; AUC 0.670, 95% CI = 0.570-0.770, p < 0.001 in females] and fatty liver (AUC 0.646, 95% CI = 0.544-0.749, p = 0.004 in males; AUC 0.733, 95% CI = 0.621-0.844, p < 0.001 in females). The present study indicates that serum LECT2 levels are increased by obesity and fatty liver, and suggests that LECT2 is a novel obesity-related protein.
白细胞细胞衍生趋化因子 2 (LECT2) 是一种在肝脏中表达的信号分子，其表达受涉及肝脏代谢的 Wnt/β-连环蛋白途径调控。然而，LECT2 在肥胖和脂肪肝中的临床相关性尚不清楚。本研究旨在确定血清 LECT2 水平是否受肥胖和脂肪肝的影响。一项包含 231 名日本成年受试者的横断面研究使用高灵敏度测定法检测 LECT2。我们评估了 LECT2 与肥胖和脂肪肝的人体测量或临床标志物之间的关联。血清 LECT2 水平的平均值为 43.5±13.6ng/mL。LECT2 与肥胖的所有人体测量指标均呈正相关：体重指数、腰围、腰臀比和腰高比 (W/Ht)。多元回归分析显示，在男性中，LECT2 与 γ-谷氨酰转肽酶 (γ-GTP)、甘油三酯和年龄独立相关，而在女性中，它与稳态模型评估比、血尿素氮、高密度脂蛋白胆固醇和 γ-GTP 相关。受试者工作特征曲线分析显示，LECT2 与肥胖相关[曲线下面积 (AUC) 男性为 0.655(95%可信区间[CI]：0.551-0.758，p=0.002)；女性为 0.670(95%CI：0.570-0.770，p<0.001)]和脂肪肝相关(AUC 男性为 0.646(95%CI：0.544-0.749，p=0.004)；女性为 0.733(95%CI：0.621-0.844，p<0.001)]。本研究表明，肥胖和脂肪肝会导致血清 LECT2 水平升高，并提示 LECT2 是一种新的肥胖相关蛋白。
