复发性早发型子痫前期受孕前预测模型的外部验证
External validation of a model for periconceptional prediction of recurrent early-onset preeclampsia.
作者信息
van Kuijk S M, Delahaije D H, Dirksen C D, Scheepers H C, Spaanderman M E, Ganzevoort W, Duvekot J J, Oudijk M A, van Pampus M G, von Dadelszen P, Peeters L L, Smits L J
机构信息
Department of Obstetrics and Gynaecology, Maastricht University Medical Centre , Maastricht , the Netherlands .
出版信息
Hypertens Pregnancy. 2014 Aug;33(3):265-76. doi: 10.3109/10641955.2013.872253. Epub 2014 Jan 6.
OBJECTIVE
To validate a previously published prediction model for recurrent early-onset preeclampsia (PE).
METHODS
We included 229 pregnant women with a history of early-onset PE and computed their risk using the prediction model, compared the predicted risk to their pregnancy outcomes and assessed performance of the model.
RESULTS
Early-onset PE recurred in 6.6% of participants. The area under the receiver operating characteristic curve was 59% (95% CI: 45-73). The model created groups that were only moderately different in terms of their risk.
CONCLUSIONS
The model's discriminate ability was poor and predictive performance insufficient to classify women into relevant risk groups.
目的
验证先前发表的早发型子痫前期（PE）复发预测模型。
方法
我们纳入了229例有早发型PE病史的孕妇，使用该预测模型计算她们的风险，将预测风险与她们的妊娠结局进行比较，并评估该模型的性能。
结果
6.6%的参与者出现早发型PE复发。受试者工作特征曲线下面积为59%（95%CI：45 - 73）。该模型创建的组在风险方面仅有适度差异。
结论
该模型的鉴别能力较差，预测性能不足以将女性分为相关风险组。
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