组织因子途径抑制物-2在胃间质瘤中的表达及其临床意义。
Expression of tissue factor pathway inhibitor-2 in gastric stromal tumor and its clinical significance.
作者信息
Wang Gui-Jun, Wang Yu-Bin, Li DI-Nuo, Li Chen, Deng Bei-Bei
机构信息
Department of General Surgery, The First Affiliated Hospital, Liaoning Medical University, Jinzhou, Liaoning 121001, P.R. China.
Liaoning Province Key Laboratory of Medical Tissue Engineering, The First Affiliated Hospital, Liaoning Medical University, Jinzhou, Liaoning 121001, P.R. China.
出版信息
Exp Ther Med. 2014 Feb;7(2):513-517. doi: 10.3892/etm.2013.1448. Epub 2013 Dec 13.
The aim of this study was to explore the expression of tissue factor pathway inhibitor-2 (TFPI-2) in gastric stromal tissue and its clinical significance. TFPI-2 expression was detected by immunohistochemical analysis, RT-PCR and western blotting in tumor, peritumoral and gastric normal tissues from 72 patients with gastric stromal tumors. The level of TFPI-2 expression was observed to be significantly higher in gastric normal tissue than in peritumoral tissue, and was significantly higher in peritumoral tissue than in tumor tissue (P<0.01). As the NIH grade increased, the level of TFPI-2 expression decreased (P<0.01). A low expression level of TFPI-2 was closely associated with invasion and metastasis of gastric stromal tumors. In conclusion, the level of TFPI-2 expression was higher in gastric normal tissue than in gastric stromal tumors. Low expression levels of TFPI-2 may be associated with invasion and metastasis of gastric stromal tumors.
本研究旨在探讨组织因子途径抑制物-2（TFPI-2）在胃间质组织中的表达及其临床意义。采用免疫组织化学分析、逆转录-聚合酶链反应（RT-PCR）和蛋白质印迹法检测72例胃间质瘤患者肿瘤组织、瘤周组织及胃正常组织中TFPI-2的表达。结果显示，胃正常组织中TFPI-2表达水平显著高于瘤周组织，瘤周组织中TFPI-2表达水平显著高于肿瘤组织（P<0.01）。随着美国国立卫生研究院（NIH）分级增加，TFPI-2表达水平降低（P<0.01）。TFPI-2低表达水平与胃间质瘤的侵袭和转移密切相关。总之，胃正常组织中TFPI-2表达水平高于胃间质瘤。TFPI-2低表达水平可能与胃间质瘤的侵袭和转移有关。
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