经皮乳腺粗针穿刺活检标本印片细胞学检查与快速染色即时诊断

Touch imprint cytology of core needle biopsy specimens for the breast and quick stain procedure for immediate diagnosis.

机构信息

Department of Obstetrics and Gynaecology University Medical Centre Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany.

出版信息

Anticancer Res. 2014 Jan;34(1):153-7.

PMID:24403456

Abstract

AIM

To investigate the validity and reproducibility of touch imprint cytology (TIC) of core needle biopsies (CNBs) in the assessment of conspicuous breast findings.

MATERIALS AND METHODS

One hundred and fifty-eight conspicuous breast findings were assessed by CNB during a two-year period in this prospective study. TIC of the CNBs was used for cytological analysis. The performance of this technique was evaluated by comparing the results with the histology of the CNB, and in cases of a subsequent surgery, with the final histology. In addition, inter-observer reproducibility was analyzed.

RESULTS

The inter-observer variability was very high (kappa-value of 0.8508; excluding inadequate imprints, 0.9502). Inadequate cellularity for cytological analysis was found in 11.4% (18/158) of findings. Compared with CNB histology, the sensitivity, specificity, positive predictive value, negative predictive value and overall accuracy of TIC was 99%, 100%, 100%, 94%, and 99%, respectively.

CONCLUSION

TIC of CNB specimens of the breast may be a valid option for providing a diagnosis without delay for a histological procedure, assuming good quality of the specimen.

摘要

目的

探讨核心针活检（CNB）触印细胞学（TIC）在评估明显乳腺病变中的有效性和可重复性。

材料和方法

在这项前瞻性研究中，在两年期间对 158 个明显的乳腺病变进行了 CNB 评估。对 CNB 进行 TIC 以进行细胞学分析。通过将该技术的结果与 CNB 的组织学进行比较，并在随后进行手术的情况下与最终组织学进行比较，评估该技术的性能。此外，还分析了观察者间的可重复性。

结果

观察者间的变异性非常高（kappa 值为 0.8508；排除不充分的印痕，kappa 值为 0.9502）。在 11.4%（18/158）的病变中发现细胞学分析的细胞数量不足。与 CNB 组织学相比，TIC 的灵敏度、特异性、阳性预测值、阴性预测值和总准确率分别为 99%、100%、100%、94%和 99%。