Rehemtulla Alnawaz
Departments of Radiation Oncology and Radiology, University of Michigan, Ann Arbor, MI.
Neoplasia. 2013 Dec;15(12):1410-20. doi: 10.1593/neo.131972.
The future of personalized oncological therapy will likely rely on evidence-based medicine to integrate all of the available evidence to delineate the most efficacious treatment option for the patient. To undertake evidence-based medicine through use of targeted therapy regimens, identification of the specific underlying causative mutation(s) driving growth and progression of a patient's tumor is imperative. Although molecular subtyping is important for planning and treatment, intraclonal genetic diversity has been recently highlighted as having significant implications for biopsy-based prognosis. Overall, delineation of the clonal architecture of a patient's cancer and how this will impact on the selection of the most efficacious therapy remain a topic of intense interest.
个性化肿瘤治疗的未来可能依赖于循证医学,以整合所有可用证据,为患者确定最有效的治疗方案。为了通过使用靶向治疗方案开展循证医学,识别驱动患者肿瘤生长和进展的特定潜在致病突变至关重要。虽然分子亚型分类对于治疗规划和治疗很重要,但克隆内基因多样性最近被强调对基于活检的预后具有重大影响。总体而言,描绘患者癌症的克隆结构及其对最有效治疗方案选择的影响仍然是一个备受关注的话题。