[The impact of acellular dermal matrix on complications of breast reconstruction using tissue expander/implant: a meta-analysis].

OBJECTIVE

To analyze the effect of acellular dermal matrix (ADM) on complications of breast reconstruction using tissue expander/implant, and to offer preliminary evidences for ADM clinical application.

METHODS

Articles published from Jan. 2010 to Oct. 2012 were searched in Pubmed, EMbase, Science Direct and CNKI database. Literatures were filtrated according to inclusive criteria. Values were extracted from included literatures; factors regarding complications were collected. Meta-analysis was performed with Stata 12. 0.

RESULTS

10 researches were included. Comparing to control group, the pooled odds ratio (OR) of overall complications, infections, hematomas/seromas, explantations are 1.51(P=0.038), 1.91(P=0.032), 1.80(P=0.005) and 2.37 (P=0.138) in ADM group In breast reconstruction using tissue expander/implant, ADM increases the respectively.

CONCLUSIONS

occurrence of hematomas/sarcomas as well as risks of infections and overall complications.