Patel Ankita Sunilbhai, Saikat Pande, Pravinbhai Patel Ronakkumar
A.R. College of Pharmacy & G.H. Patel Institute of Pharmacy, Vallabh Vidyanagar, Anand, Gujarat, India.
Curr Drug Deliv. 2014;11(3):322-31. doi: 10.2174/1567201810666140110113225.
The spherical microspheres consisting of Furosemide loaded sodium alginate and along with HPMC E50 or sodium CMC as mucoadhesive polymers in different ratios were prepared using ionic gelation technique. Calcium chloride was used as crosslinking, to retard the drug release from the mucoadhesive microspheres. The prepared mucoadhesive microspheres were subjected for evaluation of various parameters like production yield, particle size, encapsulation efficiency, mucoadhesion test and in vitro dissolution profile studies. Formulations were subjected to DSC study and SEM analysis. The in vitro release data were well fit into Higuchi and Korsmeyer-Peppas model and followed non-Fickian diffusion mechanism.
采用离子凝胶技术制备了由负载速尿的海藻酸钠以及不同比例的HPMC E50或羧甲基纤维素钠作为粘膜粘附聚合物组成的球形微球。氯化钙用作交联剂，以延缓药物从粘膜粘附微球中的释放。对制备的粘膜粘附微球进行各种参数的评估，如产率、粒径、包封率、粘膜粘附试验和体外溶出曲线研究。对制剂进行差示扫描量热法（DSC）研究和扫描电子显微镜（SEM）分析。体外释放数据很好地符合Higuchi模型和Korsmeyer-Peppas模型，并遵循非Fickian扩散机制。
