Centre de Recherche sur le Cancer, Université Laval and Département de Radio-Oncologie, Centre Hospitalier Universitaire de Québec, Québec, QC, Canada; Centre Intégré de Cancérologie de la Montérégie, Hôpital Charles-LeMoyne, Greenfield Park, QC, Canada.
Department of Radiation Oncology Maastricht Radiation Oncology (MAASTRO), GROW, University Hospital Maastricht, Maastricht, The Netherlands; Gray Institute for Radiation Oncology and Biology, The University of Oxford, The United Kingdom.
Int J Radiat Oncol Biol Phys. 2014 Feb 1;88(2):345-50. doi: 10.1016/j.ijrobp.2013.11.001.
To study the relationship between the accuracy of the dose calculation in brachytherapy and the estimations of the radiosensitivity parameter, α/β, for prostate cancer.
In this study, Monte Carlo methods and more specifically the code ALGEBRA was used to produce accurate dose calculations in the case of prostate brachytherapy. Equivalent uniform biologically effective dose was calculated for these dose distributions and was used in an iso-effectiveness relationship with external beam radiation therapy.
By considering different levels of detail in the calculations, the estimation for the α/β parameter varied from 1.9 to 6.3 Gy, compared with a value of 3.0 Gy suggested by the American Association of Physicists in Medicine Task Group 137.
Large variations of the α/β show the sensitivity of this parameter to dose calculation modality. The use of accurate dose calculation engines is critical for better evaluating the biological outcomes of treatments.
研究近距离放射治疗中剂量计算的准确性与前列腺癌放射敏感性参数α/β估计值之间的关系。
本研究采用蒙特卡罗方法，特别是使用 ALGEBRA 代码，对前列腺近距离放射治疗中的剂量进行精确计算。为这些剂量分布计算等效均匀生物有效剂量，并在与外部束放射治疗的等效效应关系中使用。
通过考虑计算中的不同详细程度，与美国医学物理学家协会工作组 137 建议的 3.0 Gy 值相比，α/β 参数的估计值从 1.9 到 6.3 Gy 不等。
α/β 的大变化表明该参数对剂量计算模式的敏感性。使用精确的剂量计算引擎对于更好地评估治疗的生物学结果至关重要。
Zotero 插件