Department of Dermatology, Indiana University School of Medicine, Indianapolis, IN 46202, USA; Richard L. Roudebush Veterans Affairs Medical Center, Indianapolis, IN 46202, USA.
Department of Pediatrics and Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Trends Immunol. 2014 Feb;35(2):49-50. doi: 10.1016/j.it.2013.12.001. Epub 2014 Jan 9.
Atopic dermatitis (AD) is characterized by allergic inflammation and itch. Thymic stromal lymphopoietin (TSLP) is a pro-allergic cytokine implicated in AD. A paper in Cell transforms the understanding of the functional repertoire of TSLP in general and in AD in particular showing that TSLP can directly stimulate sensory neurons and provoke itch.
特应性皮炎(AD)的特征是过敏炎症和瘙痒。胸腺基质淋巴细胞生成素(TSLP)是一种参与 AD 的促过敏细胞因子。发表在《Cell》上的一篇论文改变了人们对 TSLP 一般功能以及在 AD 中具体功能的理解,表明 TSLP 可以直接刺激感觉神经元并引发瘙痒。