Falchook Aaron D, Zagar Timothy M
Department of Radiation Oncology, University of North Carolina, Chapel Hill, North Carolina, United States.
Rep Pract Oncol Radiother. 2013 Jun 19;18(4):241-4. doi: 10.1016/j.rpor.2013.04.027. eCollection 2013.
In this report, we outline the case of a patient who has Ehlers-Danlos Syndrome (EDS) who received two courses of CyberKnife stereotactic radiosurgery (SRS) for metastatic non-small cell lung cancer. Patients with EDS have increased blood vessel fragility, and therefore are subject to increased risk of bleeding. There are no published data regarding the risks of hemorrhage associated with SRS for intracranial metastases in this patient population. The patient described in this case report had two courses of SRS for two sites of brain metastases. She tolerated treatment well, with no acute toxicity and good local control to date. We have also included a discussion of published literature regarding toxicity of intracranial radiation in patients with EDS.
在本报告中,我们概述了一名患有埃勒斯-当洛综合征(EDS)的患者的病例,该患者因转移性非小细胞肺癌接受了两疗程的射波刀立体定向放射外科治疗(SRS)。患有EDS的患者血管脆性增加,因此出血风险也会增加。目前尚无关于该患者群体因颅内转移接受SRS治疗相关出血风险的公开数据。本病例报告中描述的患者因两处脑转移接受了两疗程的SRS治疗。她对治疗耐受性良好,至今没有出现急性毒性反应,局部控制效果良好。我们还纳入了关于EDS患者颅内放疗毒性的已发表文献的讨论。