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蓖麻毒素A链对大鼠肝脏中携带甘露糖受体细胞的体内清除作用:对β-葡萄糖醛酸酶清除的影响

In vivo depletion of mannose receptor bearing cells from rat liver by ricin A chain: effects on clearance of beta-glucuronidase.

作者信息

Simmons B M, Stahl P D, Russell J H

出版信息

Biochem Biophys Res Commun. 1987 Jul 31;146(2):849-54. doi: 10.1016/0006-291x(87)90608-5.

Abstract

Ricin A chain has previously been shown to intoxicate macrophages in vitro following binding and endocytosis by the macrophage mannose receptor. In this report it is demonstrated that the intravenous injection of ricin A chain in nephrectomized rats leads to a prolonged plasma half-life for [125I]beta-glucuronidase, a ligand for the mannose receptor. Clearance of [125I]asialofetuin, a ligand for the galactose receptor of hepatocytes, was unaffected by injection of A chain. Microscopic examination of the livers of A chain-treated animals revealed a loss of phagocytic cells from the liver sinusoids. These results suggest that ricin A chain may be useful as a toxin specific for mannose receptor bearing cells of the reticuloendothelial system.

摘要

蓖麻毒素A链先前已被证明,在被巨噬细胞甘露糖受体结合并内吞后,可在体外使巨噬细胞中毒。本报告表明,在肾切除的大鼠中静脉注射蓖麻毒素A链会导致甘露糖受体配体[125I]β-葡萄糖醛酸酶的血浆半衰期延长。肝细胞半乳糖受体配体[125I]去唾液酸胎球蛋白的清除不受A链注射的影响。对接受A链治疗动物的肝脏进行显微镜检查发现,肝血窦中的吞噬细胞减少。这些结果表明,蓖麻毒素A链可能作为一种对网状内皮系统中带有甘露糖受体的细胞具有特异性的毒素。

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