钾通道阻断在条件性爆发神经元中诱导节律性活动。

Potassium channel blockade induces rhythmic activity in a conditional burster neuron.

作者信息

Harris-Warrick R M, Johnson B R

出版信息

Brain Res. 1987 Jul 28;416(2):381-6. doi: 10.1016/0006-8993(87)90923-1.

Abstract

In the lobster stomatogastric ganglion the Anterior Burster (AB) neuron loses its rhythmic bursting capabilities when isolated from all synaptic input. Here we report that compounds which reduce the current through several different types of potassium channels induce bursting in isolated AB neurons. These results suggest that when quiescent, this neuron has all the conductances necessary to support bursting, but bursting is actively inhibited by tonic potassium conductances.

摘要

在龙虾的口胃神经节中，前爆发神经元（AB）在与所有突触输入隔离时会丧失其节律性爆发能力。在此我们报告，能够减少通过几种不同类型钾通道电流的化合物可诱导分离的AB神经元产生爆发。这些结果表明，当该神经元处于静止状态时，它具备支持爆发所需的所有电导，但爆发受到持续性钾电导的主动抑制。