Animal Science Department, Iowa State University, Ames, Iowa, USA.
Theor Appl Genet. 1974 Jan;45(5):215-21. doi: 10.1007/BF00265002.
The main purpose of the study was to use the skin allograft reaction as a possible biological tool to estimate genetic diversity (inbreeding) in a population and to determine the relative influence on the B locus blood group locus on variation in graft rejection. In chickens, the B locus is the major histocompatibility system. One outbred and five inbred lines were used in 12 skin grafting experiments. Graft exchange also were made between certain line crosses. The study was based on 2172 allografts performed on 712 chickens.Incompatibility of the B blood group locus accounted for 3/4 of the total variance in homograft rejection within lines. For the compatible allografts only, lines accounted for more than 90% of the total variation.Graft acceptance in terms of mean survival time (MST) was highest in the most highly inbred lines and lowest in the noninbred control. The regression of genetic diversity, as a function Wright's inbreeding coefficient, as a percentage of allograft rejection may be a useful biological index of genetic diversity.
本研究的主要目的是利用皮肤同种异体反应作为一种可能的生物学工具，来评估群体中的遗传多样性（近交），并确定 B 血型基因座对移植物排斥变化的相对影响。在鸡中，B 基因座是主要组织相容性系统。在 12 次皮肤移植实验中，使用了一个杂交群体和五个近交群体。还在某些线交叉之间进行了移植物交换。该研究基于对 712 只鸡进行的 2172 次同种异体移植。B 血型基因座的不相容性占同系移植物排斥总方差的 3/4。对于相容的同种异体移植物，系占总变异的 90%以上。根据平均存活时间（MST），在高度近交系中的移植物接受率最高，而非近交对照组中的移植物接受率最低。遗传多样性的回归，作为 Wright 近交系数的函数，作为同种异体排斥的百分比，可能是遗传多样性的有用生物学指标。
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