通过调控自噬实现造血发育。

Ho(a)xing autophagy to regulate development.

机构信息

IRCCS Fondazione Santa Lucia, 00143 Rome, Italy.

IRCCS Fondazione Santa Lucia, 00143 Rome, Italy; Unit of Cell Stress and Survival, Danish Cancer Society Research Center, 2100 Copenhagen, Denmark; Department of Biology, University of Rome Tor Vergata, 00133 Rome, Italy.

出版信息

Dev Cell. 2014 Jan 13;28(1):3-4. doi: 10.1016/j.devcel.2013.12.018.

DOI:10.1016/j.devcel.2013.12.018

PMID:24434134

Abstract

In this issue of Developmental Cell, Banreti et al. (2014) demonstrate that canonical autophagy is inhibited in the Drosophila fat body by Hox transcriptional factors. This regulation involves repression of the Atg genes. Programmed developmental autophagy is thus under Hox control and may influence cell fate determination.

摘要

在本期《发育细胞》中，Banreti 等人（2014）证明了经典自噬在果蝇脂肪体中受到 Hox 转录因子的抑制。这种调节涉及 Atg 基因的抑制。程序性发育自噬因此受到 Hox 的控制，并可能影响细胞命运的决定。