一名患有双相情感障碍和特发性基底节钙化的自闭症患者出现对喹硫平有反应的紧张症。
Quetiapine responsive catatonia in an autistic patient with comorbid bipolar disorder and idiopathic basal ganglia calcification.
作者信息
Ishitobi Makoto, Kawatani Masao, Asano Mizuki, Kosaka Hirotaka, Goto Takashi, Hiratani Michio, Wada Yuji
机构信息
Department of Child and Adolescent Mental Health, National Institute of Mental Health, National Center of Neurology and Psychiatry, Japan; Department of Neuropsychiatry, University of Fukui, Japan.
Department of Pediatrics, University of Fukui, Japan.
出版信息
Brain Dev. 2014 Oct;36(9):823-5. doi: 10.1016/j.braindev.2013.12.005. Epub 2014 Jan 13.
BACKGROUND
Bipolar disorder (BD) has been linked with the manifestation of catatonia in subjects with autism spectrum disorders (ASD). Idiopathic basal ganglia calcification (IBGC) is characterized by movement disorders and various neuropsychiatric disturbances including mood disorder.
CASE
We present a patient with ASD and IBGC who developed catatonia presenting with prominent dystonic feature caused by comorbid BD, which was treated effectively with quetiapine.
CONCLUSION
In addition to considering the possibility of neurodegenerative disease, careful psychiatric interventions are important to avoid overlooking treatable catatonia associated with BD in cases of ASD presenting with both prominent dystonic features and apparent fluctuation of the mood state.
背景
双相情感障碍（BD）与自闭症谱系障碍（ASD）患者的紧张症表现有关。特发性基底节钙化（IBGC）的特征是运动障碍和包括情绪障碍在内的各种神经精神障碍。
病例
我们报告一名患有ASD和IBGC的患者，该患者因合并BD而出现具有明显肌张力障碍特征的紧张症，使用喹硫平治疗有效。
结论
除了考虑神经退行性疾病的可能性外，对于同时具有明显肌张力障碍特征和明显情绪状态波动的ASD病例，谨慎的精神科干预对于避免忽视与BD相关的可治疗性紧张症很重要。
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