Department of Biological Sciences, University of Windsor Ontario, Windsor, ON N9B 3P4, Canada.
Department of Neurosurgery, Henry Ford Hospital, Detroit, MI 48202, USA.
Cancer Cell. 2014 Jan 13;25(1):64-76. doi: 10.1016/j.ccr.2013.12.006.
The heterogeneity of brain cancers, as most solid tumors, complicates diagnosis and treatment. Identifying and targeting populations of cells driving tumorigenesis is a top priority for the cancer biology field. This is not a trivial task; considerable variance exists in the driving mutations, identifying markers, and evolutionary pressures influencing initiating cells in different individual tumors. Despite this, the ability to self-renew and differentiate must be conserved to reseed a heterogeneous tumor mass. Focusing on one example of a tumor-initiating cell population, we demonstrate that the atypical cyclin-like protein Spy1 plays a role in balancing the division properties of glioma cells with stemness properties. This mechanistic insight may provide new opportunities for therapeutic intervention of brain cancer.
脑癌的异质性，如同大多数实体肿瘤一样，使诊断和治疗变得复杂。鉴定和针对驱动肿瘤发生的细胞群体是癌症生物学领域的首要任务。这并非易事；在驱动突变、鉴定标志物以及影响不同个体肿瘤起始细胞的进化压力方面，存在相当大的差异。尽管如此，自我更新和分化的能力必须得到保留，以重新播种异质性肿瘤块。我们专注于肿瘤起始细胞群体的一个例子，证明了非典型细胞周期蛋白样蛋白 Spy1 在平衡神经胶质瘤细胞的分裂特性与干性特性方面发挥作用。这种机制上的见解可能为脑癌的治疗干预提供新的机会。
