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A targeting modality for destruction of RNA polymerase I that possesses anticancer activity.
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Small molecule BMH-compounds that inhibit RNA polymerase I and cause nucleolar stress.
Mol Cancer Ther. 2014 Nov;13(11):2537-46. doi: 10.1158/1535-7163.MCT-14-0256. Epub 2014 Oct 2.
3
Design, synthesis, and structure-activity relationships of pyridoquinazolinecarboxamides as RNA polymerase I inhibitors.
J Med Chem. 2014 Jun 12;57(11):4950-61. doi: 10.1021/jm5004842. Epub 2014 May 30.
4
Effective targeting of RNA polymerase I in treatment-resistant prostate cancer.
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Targeting RNA polymerase I transcription machinery in cancer cells by a novel monofunctional platinum-based agent.
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Targeting RNA polymerase I with an oral small molecule CX-5461 inhibits ribosomal RNA synthesis and solid tumor growth.
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Targeting ribosomal G-quadruplexes with naphthalene-diimides as RNA polymerase I inhibitors for colorectal cancer treatment.
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Expression of RNA polymerase I catalytic core is influenced by RPA12.
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Lurbinectedin Specifically Triggers the Degradation of Phosphorylated RNA Polymerase II and the Formation of DNA Breaks in Cancer Cells.
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Atypical R-loops in cancer: decoding molecular chaos for therapeutic gain.
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Anticancer drug development against ribosome synthesis and the nucleolus.
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Elevated NPM1 and FBL expression correlates with prostate cancer aggressiveness and progression.
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Ribosomal RNA transcription regulates splicing through ribosomal protein RPL22.
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Bypassing the guardian: regulated cell death pathways in p53-mutant cancers.
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4(3)-Quinazolinone: A Natural Scaffold for Drug and Agrochemical Discovery.
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Inhibition of Ribosome Biogenesis In Vivo Causes p53-Dependent Death and p53-Independent Dysfunction.
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Dysregulation of the basal RNA polymerase transcription apparatus in cancer.
Nat Rev Cancer. 2013 May;13(5):299-314. doi: 10.1038/nrc3496.
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Cancer genome landscapes.
Science. 2013 Mar 29;339(6127):1546-58. doi: 10.1126/science.1235122.
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Ubiquitylation and degradation of elongating RNA polymerase II: the last resort.
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A conserved deubiquitinating enzyme controls cell growth by regulating RNA polymerase I stability.
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Inhibition of RNA polymerase I as a therapeutic strategy to promote cancer-specific activation of p53.
Cancer Cell. 2012 Jul 10;22(1):51-65. doi: 10.1016/j.ccr.2012.05.019.
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AKT promotes rRNA synthesis and cooperates with c-MYC to stimulate ribosome biogenesis in cancer.
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Curaxins: anticancer compounds that simultaneously suppress NF-κB and activate p53 by targeting FACT.
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Quantitative proteomics and dynamic imaging of the nucleolus reveal distinct responses to UV and ionizing radiation.
Mol Cell Proteomics. 2011 Oct;10(10):M111.009241. doi: 10.1074/mcp.M111.009241. Epub 2011 Jul 21.
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Establishment and maintenance of alternative chromatin states at a multicopy gene locus.
Cell. 2011 May 13;145(4):543-54. doi: 10.1016/j.cell.2011.03.051.
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Nuclear ErbB2 enhances translation and cell growth by activating transcription of ribosomal RNA genes.
Cancer Res. 2011 Jun 15;71(12):4269-79. doi: 10.1158/0008-5472.CAN-10-3504. Epub 2011 May 9.

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