缝隙连接和连接子对半通道独立的细胞和组织功能作用——更新。
Gap junction and hemichannel-independent actions of connexins on cell and tissue functions--an update.
机构信息
Department of Biochemistry, University of Texas Health Science Center, San Antonio, TX 78229-3900, USA.
Department of Biochemistry, University of Texas Health Science Center, San Antonio, TX 78229-3900, USA.
出版信息
FEBS Lett. 2014 Apr 17;588(8):1186-92. doi: 10.1016/j.febslet.2014.01.001. Epub 2014 Jan 14.
Connexins, a family of transmembrane proteins, are components of both gap junction channels and hemichannels, which mediate the exchange of ions and small molecules between adjacent cells, and between the inside and outside of the cell, respectively. Substantial advancements have been made in the comprehension of the role of gap junctions and hemichannels in coordinating cellular events. In recent years, a plethora of studies demonstrate a role of connexin proteins in the regulation of tissue homeostasis that occurs independently of their channel activities. This is shown in the context of cell growth, adhesion, migration, apoptosis, and signaling. The major mechanisms of these channel-independent activities still remain to be discovered. In this review, we provide an updated overview on the current knowledge of gap junction- and hemichannel-independent functions of connexins, in particular, their effects on tumorigenesis, neurogenesis and disease development.
缝隙连接蛋白是一类跨膜蛋白，是间隙连接通道和半通道的组成部分，分别介导相邻细胞之间以及细胞内外的离子和小分子的交换。人们对间隙连接通道和半通道在协调细胞事件中的作用的理解已经取得了很大的进展。近年来，大量研究表明连接蛋白在组织稳态调节中的作用与其通道活性无关。这在细胞生长、黏附、迁移、凋亡和信号转导的情况下得到了体现。这些非通道依赖性活性的主要机制仍有待发现。在这篇综述中，我们提供了关于缝隙连接通道和半通道非依赖性连接蛋白功能的最新知识概述，特别是它们在肿瘤发生、神经发生和疾病发展中的作用。
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