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脂肪移植在创伤后颌面部畸形治疗中的作用。

The role of fat grafting in the treatment of posttraumatic maxillofacial deformities.

作者信息

Arcuri Francesco, Brucoli Matteo, Baragiotta Nicola, Stellin Livia, Giarda Mariangela, Benech Arnaldo

机构信息

Maxillo-Facial Surgery, Ospedale Maggiore della Carità, Novara, Italy.

出版信息

Craniomaxillofac Trauma Reconstr. 2013 Jun;6(2):121-6. doi: 10.1055/s-0033-1333877. Epub 2013 Mar 8.

Abstract

Purpose The first autologous adipose tissue grafting was performed by Neuber in 1893 with an open approach. In the early 1980s, Illouz and Fournier introduced closed liposuction. In the 1990s, Coleman published a new method of atraumatic fat transplantation. Recently, immunohistochemical studies of the extracellular matrix of the lipoaspirate showed the presence of adipose-derived stem cells. The purpose of this study is to describe the role of fat grafting in the management of posttraumatic facial deformities. Methods The study population was composed of all patients who underwent facial fat grafting between March 2008 and November 2010 as a secondary reconstructive procedure after an initial unsatisfactory treatment of the skeletal fractures. We analyzed the postoperative morphological changes by comparing the grafted side of the face to the contralateral side with the aid of a software package. Results Nineteen patients were surgically treated with fat transplantation for facial asymmetry due to a pathological postoperative healing of the soft tissue. Clinical examination and software analysis showed adequate postoperative facial balance without major complications. Conclusion Fat grafting is a very powerful tool to correct posttraumatic maxillofacial deformities and to ensure a long-term follow-up. Although we have achieved excellent clinical results in our reconstructive clinical cases, we are convinced that more complex prospective studies, enriched by long-term radiological controls, are needed to fully understand the biological behavior of the transplanted fat in the posttraumatic face.

摘要

目的 1893年,诺伊贝尔首次采用开放手术方法进行自体脂肪组织移植。20世纪80年代初,伊卢兹和富尼耶引入了封闭式抽脂术。20世纪90年代,科尔曼发表了一种无创脂肪移植的新方法。最近,对抽脂物细胞外基质的免疫组织化学研究显示存在脂肪源性干细胞。本研究的目的是描述脂肪移植在创伤后面部畸形治疗中的作用。方法 研究对象为2008年3月至2010年11月期间接受面部脂肪移植的所有患者,这些患者在最初对骨骼骨折的治疗不满意后进行了二次重建手术。我们借助软件包,通过将面部移植侧与对侧进行比较,分析术后形态变化。结果 19例患者因软组织术后病理性愈合导致面部不对称而接受了脂肪移植手术治疗。临床检查和软件分析显示术后面部平衡良好,无重大并发症。结论 脂肪移植是矫正创伤后颌面畸形和确保长期随访的一种非常有效的工具。尽管我们在重建临床病例中取得了优异的临床效果,但我们相信,需要进行更复杂的前瞻性研究,并辅以长期的放射学对照,以充分了解创伤后面部移植脂肪的生物学行为。

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