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手术治疗后颅窝表皮样囊肿的长期预后

Long term outcome in surgically treated posterior fossa epidermoids.

作者信息

Gopalakrishnan Chittur Viswanathan, Ansari Khursheed A, Nair Suresh, Menon Girish

机构信息

Department of Neurosurgery, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, Kerala 695011, India.

出版信息

Clin Neurol Neurosurg. 2014 Feb;117:93-99. doi: 10.1016/j.clineuro.2013.11.025. Epub 2013 Dec 7.

Abstract

OBJECTIVES

To study posterior fossa epidermoids treated surgically at our institute and to compare their long term outcome with respect to extent of surgical decompression.

MATERIALS AND METHODS

Retrospective analysis of 50 cases of posterior fossa epidermoid surgically treated at our institute between 1997 and 2007.

RESULTS

The mean duration from onset of symptoms to surgery was 2.5 years. Patients with cerebellopontine angle (CPA) epidermoids presented predominantly with trigeminal neuralgia (35%) and hearing loss (29%) while patients with fourth ventricle epidermoids had features of raised intracranial pressure (ICP) and gait ataxia (69.2% each). The rate of recurrence was 9% in tumors considered totally removed and 93% in those subtotally removed. Of the 17 patients with recurrences, 3 (7.9%) underwent a second operation. The mean duration of follow up at first recurrence was 9.3 years.

CONCLUSION

Based on our experience, the rate of recurrence is significantly higher after subtotal removal as compared to total removal of epidermoids on long-term follow up. Symptomatic recurrence requiring re-exploration is evident only after a long duration (∼10.9 year) following primary surgery. Hence, total removal without producing new neurological deficits should be the standard goal when operating on posterior fossa epidermoid cysts.

摘要

目的

研究我院手术治疗的后颅窝表皮样囊肿,并比较其手术减压范围的长期疗效。

材料与方法

回顾性分析我院1997年至2007年间手术治疗的50例后颅窝表皮样囊肿病例。

结果

从症状出现到手术的平均时间为2.5年。桥小脑角(CPA)表皮样囊肿患者主要表现为三叉神经痛(35%)和听力丧失(29%),而第四脑室表皮样囊肿患者具有颅内压升高和步态共济失调的特征(各占69.2%)。肿瘤全切患者的复发率为9%,次全切患者的复发率为93%。在17例复发患者中,3例(7.9%)接受了二次手术。首次复发时的平均随访时间为9.3年。

结论

根据我们的经验,长期随访显示,表皮样囊肿次全切后的复发率明显高于全切。初次手术后,有症状的复发需要再次手术,这种情况仅在较长时间(约10.9年)后才明显。因此,在后颅窝表皮样囊肿手术时,不产生新的神经功能缺损的全切应是标准目标。

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