未来的模样。
The shape of things to come.
机构信息
Department of Biological Chemistry, Howard Hughes Medical Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Department of Biological Chemistry, Howard Hughes Medical Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
出版信息
Cell. 2014 Jan 16;156(1-2):13-4. doi: 10.1016/j.cell.2013.12.037.
Surface receptors can link binding of ligands to changes in the actin-based cell cytoskeleton. Chia et al. and Chen et al. provide evidence for direct binding between the cytoplasmic tails of receptors and the WAVE complex, a regulator of the actin nucleator Arp2/3 complex, which might help to explain how environmental signals are translated into changes in morphology and motility.
表面受体可以将配体的结合与基于肌动蛋白的细胞细胞骨架的变化联系起来。Chia 等人和 Chen 等人提供了证据表明受体的细胞质尾部与 WAVE 复合物之间存在直接结合，WAVE 复合物是肌动蛋白成核因子 Arp2/3 复合物的调节剂，这可能有助于解释环境信号如何转化为形态和运动的变化。
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