一名急性淋巴细胞白血病长期幸存者发生肝细胞癌。

Hepatocellular carcinoma in a long-term survivor of acute lymphocytic leukemia.

作者信息

Fried M, Kalra J, Ilardi C F, Sawitsky A

机构信息

Department of Medicine, Queens Hospital Center, Jamaica, NY 1142.

出版信息

Cancer. 1987 Nov 15;60(10):2548-52. doi: 10.1002/1097-0142(19871115)60:10<2548::aid-cncr2820601033>3.0.co;2-h.

DOI:10.1002/1097-0142(19871115)60:10<2548::aid-cncr2820601033>3.0.co;2-h

PMID:2444327

Abstract

Hepatocellular carcinoma (HCC) occurred in a 28-year-old woman treated for acute lymphocytic leukemia (ALL) with methotrexate (MTX) and 6-mercaptopurine (6-MP), off all therapy for 15 years, who was also heterozygous for alpha-1 antitrypsin (alpha-1 AT) deficiency. MTXD is responsible for the development of HCC in this patient. The literature concerning the incidence of HCC in patients treated with MTX and 6-MP and in alpha-1 antitrypsin deficiencies is reviewed.

摘要

一名28岁女性曾接受甲氨蝶呤（MTX）和6-巯基嘌呤（6-MP）治疗急性淋巴细胞白血病（ALL），已停止所有治疗15年，该女性也是α-1抗胰蛋白酶（α-1 AT）缺乏的杂合子，发生了肝细胞癌（HCC）。MTX在该患者肝细胞癌的发生中起作用。本文综述了有关接受MTX和6-MP治疗的患者以及α-1抗胰蛋白酶缺乏患者中HCC发病率的文献。