Zekavat Omid Reza, Makarem Ali Reza, Haghpanah Sezaneh, Karamizadeh Zohreh, Javad Parvin, Karimi Mehran
Hematology Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran;
Student Research Committee, Jahrom University of Medical Sciences, Jahrom, Iran;
Iran J Med Sci. 2014 Jan;39(1):60-3.
Hydroxyurea (HU) has been successfully used in patients with β-thalassemia intermedia (β-TI). We aimed to evaluate the effect of the long-term use of HU on thyroid function in patients with β-TI. Seventy-five patients with β-TI aged≥11 years and taking HU were randomly selected during 2010 in southern Iran. Thirty-one patients with β-TI without HU were considered as a control group. Serum levels of thyroid stimulating hormone (TSH) and T4 were measured. The mean age of the participants was 22.7±5.1 years (age range=12-41 years). Serum ferritin level had no significant correlation with HU consumption (P>0.05). Overall, we detected 10 (9.4%) patients with hypothyroidism. We found that the use of HU at a dose of 8-15 mg/kg/day has no significant association with thyroid function in β-TI patients. However, due to the small sample size in our study, documentation of this finding needs further studies with higher numbers of patients.
羟基脲(HU)已成功应用于中间型β地中海贫血(β-TI)患者。我们旨在评估长期使用HU对β-TI患者甲状腺功能的影响。2010年在伊朗南部随机选取了75例年龄≥11岁且正在服用HU的β-TI患者。31例未服用HU的β-TI患者被视为对照组。检测血清促甲状腺激素(TSH)和T4水平。参与者的平均年龄为22.7±5.1岁(年龄范围=12 - 41岁)。血清铁蛋白水平与HU的服用无显著相关性(P>0.05)。总体而言,我们检测到10例(9.4%)甲状腺功能减退患者。我们发现,每天以8 - 15 mg/kg的剂量使用HU与β-TI患者的甲状腺功能无显著关联。然而,由于我们研究中的样本量较小,这一发现的记录需要更多患者的进一步研究。