School of Chemical Engineering and Environment, Beijing Institute of Technology, Beijing 100081, People's Republic of China.
Org Biomol Chem. 2014 Mar 14;12(10):1585-94. doi: 10.1039/c3ob42137f.
A novel highly enantioselective one-pot dithiolation through sulfa-Michael addition/thioesterification of thiols with α,β-unsaturated N-acylated succinimides catalysed by squaramide has been developed. This organocatalysed reaction proceeded well in high to excellent yields (up to >99%) to afford useful bioactive β-sulfated thioester derivatives with high enantioselectivities (up to 96% ee).
一种新型的高对映选择性一锅法二硫代化反应，通过磺酰胺催化的硫醇与α,β-不饱和 N-酰基琥珀酰亚胺的硫迈克尔加成/硫酯化反应来实现。这种有机催化反应在高至优异的产率（高达>99%）下进行，得到了具有高对映选择性（高达 96%ee）的有用的生物活性β-硫酸化硫酯衍生物。
