通过高灵敏度带选择性纯位移 NMR 光谱学测定非对映体比例。
Diastereomeric ratio determination by high sensitivity band-selective pure shift NMR spectroscopy.
机构信息
School of Chemistry, University of Manchester, Oxford Road, Manchester, M13 9PL, UK.
出版信息
Chem Commun (Camb). 2014 Mar 7;50(19):2512-4. doi: 10.1039/c3cc49659g. Epub 2014 Jan 24.
PMID:24458213
Abstract
An NMR method is reported that allows diastereomeric ratios to be determined even in crowded spectra or where chemical shift differences are small compared to multiplet widths. Band-selective pure shift NMR collapses multiplets to singlets, greatly improving spectral resolution while largely retaining, or even enhancing, signal-to-noise ratio.
摘要
报道了一种 NMR 方法，即使在拥挤的光谱或化学位移差异相对于峰裂间距较小时，也能确定非对映体比例。带选择性纯位移 NMR 将多重峰压缩为单峰，在大大提高光谱分辨率的同时，还保持甚至增强了信噪比。
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