Hamiche Ali, Shuaib Muhammad
Biochim Biophys Acta. 2013 Mar-Apr;1819(3-4):230-237. doi: 10.1016/j.bbagrm.2011.08.009.
Chromatin is a highly dynamic nucleoprotein structure, which orchestrates all nuclear process from DNA replication to DNA repair, fromtranscription to recombination. The proper in vivo assembly of nucleosome, the basic repeating unit of chromatin, requires the deposition of two H3-H4 dimer pairs followed by the addition of two dimers of H2A and H2B. Histone chaperones are responsible for delivery of histones to the site of chromatin assembly and histone deposition onto DNA, histone exchange and removal. Distinct factors have been found associated with different histone H3 variants, which facilitate their deposition. Unraveling the mechanism of histone depositionby specific chaperones is of key importance to epigenetic regulation. In this review, we focus on histoneH3 variants and their deposition mechanisms. This article is part of a Special Issue entitled: Histone chaperones and Chromatin assembly.
染色质是一种高度动态的核蛋白结构，它协调从DNA复制到DNA修复、从转录到重组的所有核过程。染色质的基本重复单元核小体在体内的正确组装需要先沉积两个H3-H4二聚体对，然后再添加两个H2A和H2B二聚体。组蛋白伴侣负责将组蛋白递送至染色质组装位点，并将组蛋白沉积到DNA上、进行组蛋白交换和去除。已发现不同的因子与不同的组蛋白H3变体相关联，这些因子有助于它们的沉积。阐明特定伴侣介导的组蛋白沉积机制对于表观遗传调控至关重要。在本综述中，我们聚焦于组蛋白H3变体及其沉积机制。本文是名为“组蛋白伴侣与染色质组装”的特刊的一部分。
