比利时儿科医生使用抑酸药物的处方模式变化：对1997 - 2009年国家数据库的分析
Changes in prescription patterns of acid-suppressant medications by Belgian pediatricians: analysis of the national database, [1997-2009].
作者信息
De Bruyne Pauline, Christiaens Thierry, Vander Stichele Robert, Van Winckel Myriam
机构信息
*Department of Pediatrics †Department of Family Medicine and Primary Health Care ‡Heymans Institute of Pharmacology, Faculty of Medicine and Health Sciences §Department of Pediatric Gastroenterology, Ghent University Hospital, Ghent, Belgium.
出版信息
J Pediatr Gastroenterol Nutr. 2014 Feb;58(2):220-5. doi: 10.1097/MPG.0b013e3182a3b04e.
OBJECTIVE
The aim of this study was to examine the trend in the prescribing of proton pump inhibitors (PPIs) and histamine 2-receptor antagonists (H2-RAs) for children in Belgium from 1997 to 2009 to encourage discussion regarding appropriate clinical use.
METHODS
Monthly claim-based data for PPIs and H2-RAs were obtained from the national health insurance database (Pharmanet 1997-2009).
RESULTS
The total monthly volume of all reimbursed antireflux medications, prescribed by Belgian pediatricians, increased 7-fold from 20,782 daily defined doses (DDDs) in January 1997 to 142,912 DDDs in June 2009. During this study period, reimbursed volume of H2-RAs increased from 2575 to 38,996 DDDs and of PPIs from 3472 to 103,926 DDDs per month.
CONCLUSIONS
PPI use has increased substantially in children. Its use does not seem to be commensurate with the prevalence of gastroesophageal reflux disease in children. This study encourages clinical discussion regarding well-considered use of these drugs in children.
目的
本研究旨在调查1997年至2009年比利时儿童使用质子泵抑制剂（PPI）和组胺2受体拮抗剂（H2-RA）的处方趋势，以促进关于合理临床应用的讨论。
方法
从国家健康保险数据库（Pharmanet 1997 - 2009）获取PPI和H2-RA基于月度报销的数据。
结果
比利时儿科医生开具的所有报销抗反流药物的月度总量从1997年1月的20782日规定剂量（DDD）增加到2009年6月的142912 DDD，增长了7倍。在本研究期间，H2-RA的报销量从每月2575 DDD增加到38996 DDD，PPI的报销量从每月3472 DDD增加到103926 DDD。
结论
儿童中PPI的使用大幅增加。其使用似乎与儿童胃食管反流病的患病率不相称。本研究鼓励就这些药物在儿童中的合理使用进行临床讨论。
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