Kotler Samuel A, Walsh Patrick, Brender Jeffrey R, Ramamoorthy Ayyalusamy
Biophysics and Department of Chemistry, University of Michigan, 930 N. University Ave, Ann Arbor, MI 48109-1055, USA.
Chem Soc Rev. 2014 Oct 7;43(19):6692-700. doi: 10.1039/c3cs60431d.
The association of the amyloid-β (Aβ) peptide with cellular membranes is hypothesized to be the underlying phenomenon of neurotoxicity in Alzheimer's disease. Misfolding of proteins and peptides, as is the case with Aβ, follows a progression from a monomeric state, through intermediates, ending at long, unbranched amyloid fibers. This tutorial review offers a perspective on the association of toxic Aβ structures with membranes as well as details of membrane-associated mechanisms of toxicity.
淀粉样β(Aβ)肽与细胞膜的关联被认为是阿尔茨海默病神经毒性的潜在现象。与Aβ一样,蛋白质和肽的错误折叠遵循从单体状态开始,经过中间体,最终形成长的、无分支的淀粉样纤维的过程。本教程综述提供了关于有毒Aβ结构与膜的关联以及膜相关毒性机制细节的观点。