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单次吸入二甲苯后急性血小板减少症——病例报告

[Acute-onset thrombocytopenia following single inhalation xylene exposure--a case report].

作者信息

Siwek-Iwanicka Jolanta, Chwaluk Agnieszka

机构信息

Oddział Chorób Wewnetrznych Wojewódzkiego Szpitala Specjalistycznego w Białej Podlaskiej.

Zakład Rehabilitacji Medycznej Wydziału Wychowania Fizycznego i Sportu w Białej Podlaskiej, Akademii Wychowania Fizycznego, Józefa Piłsudskiego w Warszawie.

出版信息

Przegl Lek. 2013;70(8):681-3.

Abstract

Bone marrow damage is a well known consequence of chronic exposure to benzene and its homologues, which include xylene. Anemia dominates in the clinical picture and isolated thrombocytopenia is a rare symptom. We have not found reports of isolated thrombocytopenia in the course of acute xylene poisoning. A 56-years old man with thrombocytopenia, was admitted, after two days of work with concrete floor paint containing up to 17% xylene. The thrombocytes' nadir (29 x 10(9)/L) occurred on the fourth day from the exposure. After treatment with dexamethasone the platelet count normalized. There were no signs of hemorrhagic diathesis. Clinicians should be aware of the possibility of thrombocytopenia in patients acutely exposed to xylene.

摘要

骨髓损伤是长期接触苯及其同系物(包括二甲苯)的一个众所周知的后果。贫血在临床表现中占主导,而单纯性血小板减少是一种罕见症状。我们尚未发现急性二甲苯中毒过程中出现单纯性血小板减少的报道。一名56岁的血小板减少男性患者,在使用含高达17%二甲苯的混凝土地面漆工作两天后入院。血小板计数最低点(29×10⁹/L)出现在接触后的第四天。用地塞米松治疗后血小板计数恢复正常。没有出血素质的迹象。临床医生应意识到急性接触二甲苯的患者有可能出现血小板减少。

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