英夫利昔单抗治疗后 2 例炎症性肠病患儿发生播散性结核。
Disseminated tuberculosis in 2 children with inflammatory bowel disease receiving infliximab.
机构信息
From the *Sections of Infectious Diseases; †Emergency Medicine; and †Gastroenterology and Nutrition, Department of Pediatrics; and §Department of Pediatric Radiology, Baylor College of Medicine, Houston, TX.
出版信息
Pediatr Infect Dis J. 2014 Jul;33(7):779-81. doi: 10.1097/INF.0000000000000286.
Patients with inflammatory bowel disease are predisposed to opportunistic infections. We report 2 cases of disseminated tuberculosis in adolescents receiving a TNF antagonist, infliximab. Both had negative baseline tuberculin skin tests. Multimodal testing using tuberculin skin tests and interferon gamma release assays at the time of inflammatory bowel disease diagnosis and annually may increase the sensitivity of LTBI testing in these high risk children.
炎症性肠病患者易发生机会性感染。我们报告了 2 例接受 TNF 拮抗剂英夫利昔单抗治疗的青少年播散性结核病例。他们的结核菌素皮肤试验均为阴性。在炎症性肠病诊断时和每年使用结核菌素皮肤试验和干扰素γ释放试验进行多模式检测可能会提高这些高危儿童 LTBI 检测的灵敏度。
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