载脂蛋白与临床孤立综合征中的新 MRI 病变和深部灰质萎缩有关。

Apolipoproteins are associated with new MRI lesions and deep grey matter atrophy in clinically isolated syndromes.

机构信息

Department of Biotechnical and Clinical Laboratory Sciences, State University of New York, Buffalo, New York, USA.

Department of Neurology, State University of New York, Buffalo, New York, USA.

出版信息

J Neurol Neurosurg Psychiatry. 2014 Aug;85(8):859-64. doi: 10.1136/jnnp-2013-307106. Epub 2014 Jan 27.

DOI:10.1136/jnnp-2013-307106

PMID:24470599

Abstract

OBJECTIVES

There is increasing evidence that serum lipoprotein cholesterol biomarkers are associated with disease progression in clinically isolated syndromes (CIS). Apolipoproteins (Apo) are recognition ligands that mediate the physiological interactions of cholesterol-containing lipoproteins. The objective of this study was to investigate whether serum Apo levels are associated with CIS disease progression.

METHODS

ApoB, ApoAI, ApoAII, ApoE and lipoprotein (a) (Lpa) levels were measured in serum samples obtained prior to the start of treatment from 181 CIS patients (123 women, 58 men, 68% women; mean age: 28.1±SD 8.1 years). All patients were treated with intramuscular interferon-β as part of the prospective study. Clinical and MRI assessments were obtained at baseline, 6, 12 and 24 months after start of interferon-β treatment.

RESULTS

Greater ApoB levels were associated with increased number of new T2 lesions (p<0.001) and increased number of new or enlarging T2 lesions (p<0.001) over 2 years. Each 10 mg/dL of greater baseline ApoB is associated with a 16% increase in the number of new T2 lesions over 2 years. ApoAI, ApoAII, ApoE and Lpa were not associated with T2 lesions. Greater ApoE levels were associated with greater deep grey matter atrophy (partial correlation rp=-0.28, p<0.001). Each 1 mg/dL increment in ApoE levels was associated with a 1% increase in deep grey matter atrophy over 2 years.

CONCLUSIONS

Serum ApoB levels are associated with new lesion accumulation whereas ApoE levels are associated with deep grey matter atrophy in high risk CIS patients treated with interferon β-1a.

摘要

目的

越来越多的证据表明，血清脂蛋白胆固醇生物标志物与临床孤立综合征（CIS）的疾病进展有关。载脂蛋白（Apo）是介导含胆固醇脂蛋白生理相互作用的识别配体。本研究旨在探讨血清 Apo 水平是否与 CIS 疾病进展有关。

方法

在开始治疗前，从 181 例 CIS 患者（123 名女性，58 名男性，女性占 68%；平均年龄：28.1±8.1 岁）的血清样本中测量了 ApoB、ApoAI、ApoAII、ApoE 和脂蛋白（a）（Lpa）水平。所有患者均接受肌肉内干扰素-β治疗，作为前瞻性研究的一部分。在开始干扰素-β治疗后 6、12 和 24 个月进行临床和 MRI 评估。

结果

较高的 ApoB 水平与 2 年内新 T2 病变数量增加（p<0.001）和新或扩大 T2 病变数量增加（p<0.001）有关。基线时 ApoB 每增加 10mg/dL，2 年内新 T2 病变数量增加 16%。ApoAI、ApoAII、ApoE 和 Lpa 与 T2 病变无关。较高的 ApoE 水平与深部灰质萎缩程度增加相关（偏相关 rp=-0.28，p<0.001）。ApoE 水平每增加 1mg/dL，2 年内深部灰质萎缩增加 1%。