Am J Psychiatry. 2014 May;171(5):557-63. doi: 10.1176/appi.ajp.2013.13070943.
The authors examined whether serologically confirmed maternal exposure to influenza was associated with an increased risk of bipolar disorder in the offspring and with subtypes of bipolar disorder, with and without psychotic features.
The study used a nested case-control design in the Child Health and Development Study birth cohort. In all, 85 individuals with bipolar disorder were identified following extensive ascertainment and diagnostic assessment and matched to 170 comparison subjects in the analysis. Serological documentation of maternal exposure to influenza was determined using the hemagglutination inhibition assay.
No association was observed between serologically documented maternal exposure to influenza and bipolar disorder in offspring. However, maternal serological influenza exposure was related to a significant fivefold greater risk of bipolar disorder with psychotic features.
The results suggest that maternal influenza exposure may increase the risk for offspring to develop bipolar disorder with psychotic features. Taken together with earlier associations between prenatal influenza exposure and schizophrenia, these results may suggest that prenatal influenza is a risk factor for psychosis rather than for a specific psychotic disorder diagnosis.
作者研究了血清学证实的母体流感暴露是否与后代双相情感障碍的风险增加有关，以及是否与伴有或不伴有精神病特征的双相情感障碍亚型有关。
该研究使用了儿童健康与发展研究队列中的巢式病例对照设计。总共在广泛的确定和诊断评估后确定了 85 名双相情感障碍患者，并在分析中与 170 名对照受试者进行了匹配。使用血凝抑制测定法确定母体流感血清学暴露的血清学记录。
血清学记录的母体流感暴露与后代的双相情感障碍之间没有关联。然而，母体血清学流感暴露与伴有精神病特征的双相情感障碍的风险显著增加五倍相关。
结果表明，母体流感暴露可能会增加后代出现伴有精神病特征的双相情感障碍的风险。结合之前关于产前流感暴露与精神分裂症之间的关联，这些结果可能表明产前流感是精神病的危险因素，而不是特定的精神病诊断的危险因素。
