The M gamma chain of human fetal hemoglobin. - Suppr | 超能文献

The M gamma chain of human fetal hemoglobin.

作者信息

Huisman T H, Kutlar F, Kutlar A, Wilson J B, Harris H F

机构信息

Department of Cell and Molecular Biology, Medical College of Georgia, Augusta 30912-3331.

出版信息

Prog Clin Biol Res. 1987;251:507-17.

Abstract

A new gamma chain of human fetal hemoglobin, the M gamma chain, has been detected by high performance liquid chromatography (HPLC). It is characterized by a Leu----Met replacement at position gamma 141; no other structural variations have been found. The M gamma chain has been observed in red cell lysates of subjects with a heterozygosity for one of many types of hereditary persistence of fetal hemoglobin (HPFH), in sickle cell anemia, and in a few cord blood samples. At present, the genetic cause of this newly discovered heterogeneity is not known; an infidelity in translation or the existence of an unrecognized gamma globin gene should be considered.

摘要

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