萨斯喀彻温省肺炎球菌结合疫苗使用与呼吸道感染和中耳炎就诊的关系。
Respiratory infection and otitis media visits in relation to pneumococcal conjugate vaccine use in Saskatchewan.
机构信息
Quebec National Public Health Institute, Quebec City, Quebec;
Department of Pediatrics, University of Saskatchewan, Saskatoon;
出版信息
Can J Infect Dis Med Microbiol. 2013 Winter;24(4):179-84. doi: 10.1155/2013/385652.
BACKGROUND
In Saskatchewan, pneumococcal conjugate vaccination (PCV) was offered to high-risk children in 2002 and to all infants in 2005.
OBJECTIVE
To describe trends in the frequency of medical visits for lower respiratory tract infection (LRI) and otitis media (OM) in relation to PCV use during the period 1990 to 2008.
METHODS
Statistics regarding the number of children covered by the health insurance plan, PCV administration, and medical visits with a diagnostic code associated with LRI and OM were provided by Saskatchewan Health. Monthly rates were analyzed using dynamic state space models.
RESULTS
In all series, there was a marked seasonal cycle and some higher-than-expected winter peak values, possibly associated with epidemics of specific respiratory viruses. Three abrupt decreases in baseline rate were observed for LRI and the final one, in February 2007, could be related to the increased proportion of children vaccinated with PCV. There was no statistical correlation between PCV use and OM visit frequency.
CONCLUSION
Many environmental, biological and administrative factors may influence health services use, and an effect of low magnitude of a particular vaccine pertaining to nonspecific outcomes could be obscured in time-series analyses.
背景
在萨斯喀彻温省，肺炎球菌结合疫苗（PCV）于 2002 年开始为高危儿童接种，2005 年开始为所有婴儿接种。
目的
描述 1990 年至 2008 年期间 PCV 使用与下呼吸道感染（LRI）和中耳炎（OM）就诊频率之间的关系。
方法
萨斯喀彻温省卫生部门提供了有关医疗保险计划覆盖的儿童人数、PCV 接种和与 LRI 和 OM 相关诊断代码就诊的统计数据。使用动态状态空间模型分析了每月的比率。
结果
在所有系列中，都存在明显的季节性周期和一些高于预期的冬季高峰值，可能与特定呼吸道病毒的流行有关。对于 LRI，观察到三个基线率的急剧下降，最后一个下降发生在 2007 年 2 月，可能与 PCV 接种儿童比例增加有关。PCV 使用与 OM 就诊频率之间没有统计学相关性。
结论
许多环境、生物和行政因素可能会影响卫生服务的使用，而特定疫苗对非特异性结果的低幅度影响可能会在时间序列分析中被掩盖。
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