South Australian Institute of Ophthalmology, University of Adelaide, Adelaide, South Australia.
South Australian Institute of Ophthalmology, University of Adelaide, Adelaide, South Australia.
Ophthalmology. 2014 Jun;121(6):1203-11. doi: 10.1016/j.ophtha.2013.12.011. Epub 2014 Feb 1.
To investigate the effect of topical glucose on visual parameters in individuals with primary open-angle glaucoma (POAG).
Double-blind, randomized, crossover study.
Nondiabetic pseudophakic patients with definite POAG were recruited; 29 eyes of 16 individuals participated in study 1. A follow-up study (study 2) included 14 eyes of 7 individuals.
Eyes were randomly allocated to receive 50% glucose or saline eye drops every 5 minutes for 60 minutes.
The contrast sensitivity and best-corrected logarithm of the minimum angle of resolution (logMAR).
The 50% glucose reached the vitreous in pseudophakic but not phakic individuals. Glucose significantly improved the mean contrast sensitivity at 12 cycles/degree compared with 0.9% saline by 0.26 log units (95% confidence interval [CI], 0.13-0.38; P < 0.001) and 0.40 log units (95% CI, 0.17-0.60; P < 0.001) in the follow-up study. The intraocular pressure, refraction, and central corneal thickness were not affected by glucose; age was not a significant predictor of the response.
Topical glucose temporarily improves psychophysical visual parameters in some individuals with POAG, suggesting that neuronal energy substrate delivery to the vitreous reservoir may recover function of "sick" retinal neurons.
研究局部葡萄糖对原发性开角型青光眼（POAG）患者视觉参数的影响。
双盲、随机、交叉研究。
招募了非糖尿病性人工晶状体眼的明确 POAG 患者；16 名个体的 29 只眼参与了研究 1。一项随访研究（研究 2）包括 7 名个体的 14 只眼。
眼睛随机分配接受 50%葡萄糖或生理盐水滴眼，每 5 分钟 1 次，共 60 分钟。
对比敏感度和最佳矫正最小分辨角对数（logMAR）。
50%葡萄糖到达了人工晶状体眼的玻璃体，但未到达有晶状体眼的玻璃体。与 0.9%生理盐水相比，葡萄糖在 12 个周期/度时显著提高了平均对比敏感度，差异为 0.26 log 单位（95%置信区间，0.13-0.38；P<0.001）和 0.40 log 单位（95%置信区间，0.17-0.60；P<0.001）。在随访研究中，眼内压、屈光度和中央角膜厚度不受葡萄糖影响；年龄不是反应的显著预测因素。
局部葡萄糖可暂时改善一些 POAG 患者的心理物理视觉参数，提示玻璃体储库的神经元能量底物输送可能恢复“患病”视网膜神经元的功能。
Zotero 插件