BAG-3和热休克蛋白70与T细胞淋巴瘤中CD30表达的相关性
Correlation of BAG-3 and heat shock protein 70 with CD30 expression in T-cell lymphomas.
作者信息
Jiang L, Zhao Z, Menke D M, Rizzo K A
机构信息
Department of Pathology and Laboratory Medicine, Mayo Clinic, Jacksonville, FL.
Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN.
出版信息
Sci Rep. 2014 Feb 4;4:3952. doi: 10.1038/srep03952.
T-cell lymphomas are aggressive lymphomas with decreased prognosis and resistance to therapy. BAG-3 and heat shock protein 70 (HSP70) function in chemotherapeutic resistance and cellular survival. Expression of BAG-3 has not been investigated in T cell lymphomas. We investigated fifty cases including benign, systemic and cutaneous T cell lymphomas. Benign T cells were negative for BAG-3 and HSP70 immunohistochemical staining. BAG-3 expression correlated with increased HSP70 expression in a subset of systemic T cell lymphoma cases co-expressing the CD30 antigen. Correlation between BAG-3, HSP70 and CD30 expression was not seen in cutaneous T cell lymphoma cases. However, these cases showed a significant increase in BAG-3 staining when compared to CD30 negative systemic T cell lymphoma cases. The differential protein expression profile of BAG-3 and HSP70 may indicate a specific role for these proteins and the ubiquitin-proteasome system/autophagy in T cell lymphomas which may help guide future targeted therapy.
T细胞淋巴瘤是侵袭性淋巴瘤，预后较差且对治疗有抗性。BAG-3和热休克蛋白70（HSP70）在化疗抗性和细胞存活中发挥作用。尚未在T细胞淋巴瘤中研究BAG-3的表达。我们研究了50例病例，包括良性、系统性和皮肤性T细胞淋巴瘤。良性T细胞的BAG-3和HSP70免疫组化染色均为阴性。在共表达CD30抗原的一部分系统性T细胞淋巴瘤病例中，BAG-3表达与HSP70表达增加相关。在皮肤性T细胞淋巴瘤病例中未观察到BAG-3、HSP70和CD30表达之间的相关性。然而，与CD30阴性的系统性T细胞淋巴瘤病例相比，这些病例的BAG-3染色显著增加。BAG-3和HSP70的差异蛋白表达谱可能表明这些蛋白质以及泛素-蛋白酶体系统/自噬在T细胞淋巴瘤中具有特定作用，这可能有助于指导未来的靶向治疗。
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