癌胚抗原相关细胞黏附分子6（CEACAM6）促进胃癌的肿瘤迁移、侵袭和转移。
CEACAM6 promotes tumor migration, invasion, and metastasis in gastric cancer.
作者信息
Zhang Yunqiang, Zang Mingde, Li Jianfang, Ji Jun, Zhang Jianian, Liu Xiaolei, Qu Ying, Su Liping, Li Chen, Yu Yinyan, Zhu Zhenggang, Liu Bingya, Yan Min
机构信息
Shanghai Key Laboratory of Gastric Neoplasms, Department of Surgery, Shanghai Institute of Digestive Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
出版信息
Acta Biochim Biophys Sin (Shanghai). 2014 Apr;46(4):283-90. doi: 10.1093/abbs/gmu001. Epub 2014 Feb 3.
Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) shows increased expression in a wide variety of human cancers, and its over-expression is associated with enhanced migration, invasion, and in vivo metastasis. Here, we reported that CEACAM6 was up-regulated in gastric cancer (GC) cell lines and tumor tissues. Over-expression of CEACAM6 in MKN-45 and SGC-7901 GC cells promoted migration and invasion in vitro and metastasis in athymic mice, whereas migration and invasion of MKN-28 and SNU-16 GC cells were suppressed by knockdown of CEACAM6. We also observed that steroid receptor coactivator (C-SRC) phosphorylation was increased when CEACAM6 was over-expressed in SGC-7901 cells. Taken together, these results suggested that CEACAM6 functions as an oncoprotein in GC and may be an important metastatic biomarker and therapeutic target.
癌胚抗原相关细胞粘附分子6（CEACAM6）在多种人类癌症中表达增加，其过表达与迁移、侵袭及体内转移增强相关。在此，我们报道CEACAM6在胃癌（GC）细胞系和肿瘤组织中上调。CEACAM6在MKN - 45和SGC - 7901胃癌细胞中的过表达促进了体外迁移和侵袭以及无胸腺小鼠体内的转移，而CEACAM6的敲低则抑制了MKN - 28和SNU - 16胃癌细胞的迁移和侵袭。我们还观察到，当CEACAM6在SGC - 7901细胞中过表达时，类固醇受体辅激活因子（C - SRC）磷酸化增加。综上所述，这些结果表明CEACAM6在胃癌中作为一种癌蛋白发挥作用，可能是一个重要的转移生物标志物和治疗靶点。
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