多功能核酸用于肿瘤细胞治疗。
Multifunctional nucleic acids for tumor cell treatment.
机构信息
1 Life and Medical Sciences Institute, University of Bonn , Bonn, Germany .
出版信息
Nucleic Acid Ther. 2014 Apr;24(2):171-7. doi: 10.1089/nat.2013.0472. Epub 2014 Feb 4.
Abstract
We report on a multifunctional nucleic acid, termed AptamiR, composed of an aptamer domain and an antimiR domain. This composition mediates cell specific delivery of antimiR molecules for silencing of endogenous micro RNA. The introduced multifunctional molecule preserves cell targeting, anti-proliferative and antimiR function in one 37-nucleotide nucleic acid molecule. It inhibits cancer cell growth and induces gene expression that is pathologically damped by an oncomir. These findings will have a strong impact on future developments regarding aptamer- and antimiR-related applications for tumor targeting and treatment.
摘要
我们报告了一种多功能核酸，称为 AptamiR，它由一个适体结构域和一个 antimiR 结构域组成。这种组合介导了针对内源性 microRNA 的沉默的 antimiR 分子的细胞特异性递送。所引入的多功能分子在一个 37 个核苷酸的核酸分子中保留了细胞靶向性、抗增殖性和 antimiR 功能。它抑制了癌细胞的生长，并诱导了由癌基因抑制的基因表达。这些发现将对未来基于适体和 antimiR 的肿瘤靶向和治疗应用的发展产生重大影响。
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