Ross B, Steinmann J, Buer J, Dusse F, Jakob H, Schneemann H, Hugo-Hanke S, Bräutigam S, Sanewski A, Kundt R, Parohl N, Weidler K, Witzke O, Popp W
Krankenhaushygiene, Universitätsklinikum Essen.
Institut für Medizinische Mikrobiologie, Universitätsklinikum Essen.
Dtsch Med Wochenschr. 2014 Feb;139(7):323-6. doi: 10.1055/s-0033-1360059. Epub 2014 Feb 4.
In February 2013, 5 patients in an intensive care unit (ICU) were found to have positive blood cultures with Ralstonia pickettii within one week. Because all patients got intravenous therapy, improper work of a staff member was suspected. Some days later, a 6th patient was found with a positive blood culture of Ralstonia pickettii in another department of the hospital.
Hygienic investigations showed no evidence of failures in preparation of intravenous therapy. All patients were on different intravenous drugs, but every patient had received glucose 5 % and magnesium. We examined samples of glucose and magnesia as well as samples from environment. RESULTS AND COURSE: Glucose and magnesium samples were examined by membrane filter method. Ralstonia pitteckii was detected in some Magnesium vials. We concluded, that contamination of Magnesium vials might have been the reason for blood stream infection of patients. Pharmacists and authorities were informed and all vials were collected and replaced by vials from another company. Later a nationwide recall of Magnesium vials was performed by the producing company. No further Ralstonia pickettii was found in blood cultures in our hospital.
Unusual pathogens in blood cultures should lead to reflection of rarer causes such as contamination of medicines.
2013年2月,重症监护病房(ICU)的5名患者在一周内血培养检测出皮氏罗尔斯顿菌呈阳性。由于所有患者均接受了静脉治疗,怀疑是一名工作人员操作不当所致。数日后,医院另一科室的一名患者血培养也检测出皮氏罗尔斯顿菌呈阳性。
卫生学调查显示静脉治疗准备过程中没有失误迹象。所有患者使用的静脉药物不同,但每位患者都接受过5%葡萄糖和镁剂治疗。我们检查了葡萄糖和镁剂样本以及环境样本。结果与病程:采用薄膜过滤法检查葡萄糖和镁剂样本。在部分镁剂瓶中检测出皮氏罗尔斯顿菌。我们得出结论,镁剂瓶受到污染可能是患者发生血流感染的原因。已通知药剂师和相关部门,收集了所有镁剂瓶,并用另一家公司生产的镁剂瓶进行替换。随后,生产公司在全国范围内召回了镁剂瓶。我院血培养中未再发现皮氏罗尔斯顿菌。
血培养中出现不常见病原体应促使人们思考如药品污染等较为罕见的原因。