Department of Neurology, the First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, China.
Diabetol Metab Syndr. 2013 Oct 21;5(1):63. doi: 10.1186/1758-5996-5-63.
The pathogenesis between cerebral vascular disease (CVD) and the endothelial dysfunction (ETD) remains elusive in diabetes. Therefore, we investigated the expression of partial vasoactivators which be closely relative to ETD in CVD susceptible brain regions in the diabetic rat. The aim was to search some possible pathogenesis.
Diabetes was induced by a single intraperitoneal injection of streptozotocin and a high lipid/sugar diet. The expression of vasoactivators ET-1, CGRP, VCAM-1, ICAM-1 and P-selectin were assessed by immunohistochemical staining and measurement of optic density of positive cells in the frontal and temporal lobe, basal ganglia and thalamus at 4 weeks after establishment of the diabetic model.
The expression of ET-1, VCAM-1, ICAM-1 and P-selectin significantly increased and CGRP significantly decreased in the diabetic group, and the expression of these vasoactivators was significantly different among the frontal, temporal lobe, basal ganglia and thalamus, and among the emotion, splanchno-motor and neuroendocrine center in the diabetic group.
Diabetes alters the expression of partial vasoactivators in cerebral vascular disease susceptible regions of the diabetic rat. Therefore, we suggested that CVD complications in diabetes are partly caused by ETD via an imbalance expression of endothelial vasoactivators, which might be associated with dysfunction of emotion, autonomic nerve and endocrine center. However, further studies are warranted.
脑血管疾病（CVD）与内皮功能障碍（EDT）之间的发病机制在糖尿病中仍难以捉摸。因此，我们研究了与 EDT 密切相关的部分血管活性物质在糖尿病大鼠易患 CVD 的脑区中的表达。目的是寻找一些可能的发病机制。
通过单次腹腔注射链脲佐菌素和高脂质/高糖饮食诱导糖尿病。在建立糖尿病模型 4 周后，通过免疫组织化学染色和阳性细胞光密度测量评估血管活性物质 ET-1、CGRP、VCAM-1、ICAM-1 和 P-选择素在前额和颞叶、基底神经节和丘脑的表达。
糖尿病组 ET-1、VCAM-1、ICAM-1 和 P-选择素的表达明显增加，CGRP 的表达明显降低，且这些血管活性物质在糖尿病组的额叶、颞叶、基底神经节和丘脑之间以及情绪、内脏运动和神经内分泌中心之间的表达存在显著差异。
糖尿病改变了糖尿病大鼠易患 CVD 区域部分血管活性物质的表达。因此，我们认为糖尿病的 CVD 并发症部分是由于内皮血管活性物质的失衡表达引起的内皮功能障碍引起的，这可能与情绪、自主神经和内分泌中心的功能障碍有关。然而，还需要进一步的研究。
