基于社区的老年人群队列中抑郁症状与认知之间的因果关联。
Causal associations between depression symptoms and cognition in a community-based cohort of older adults.
作者信息
Bunce David, Batterham Philip J, Christensen Helen, Mackinnon Andrew J
机构信息
Institute of Psychological Sciences, Faculty of Medicine and Health, University of Leeds, Leeds, United Kingdom.
Centre for Mental Health Research, The Australian National University, Canberra, Australia.
出版信息
Am J Geriatr Psychiatry. 2014 Dec;22(12):1583-91. doi: 10.1016/j.jagp.2014.01.004. Epub 2014 Jan 8.
OBJECTIVE
To evaluate the temporal association between depression symptoms and cognitive function in older adults over a 4-year period.
METHODS
Using a longitudinal, cross-lagged, population-based design, we studied depression symptoms and cognitive domains (including processing speed, verbal fluency, face and word recognition, episodic memory, and simple and choice reaction time) in 896 community-dwelling adults aged 70-97 years.
RESULTS
Cross-lagged structural equation models suggested that initial depression symptoms affected subsequent processing speed and simple and choice reaction time but that cognition did not predict depression symptoms over time. The associations between depression and cognitive variables were attenuated when the models were adjusted for sensory impairment, physical health, and locus of control.
CONCLUSION
The findings suggest that, causally, depression precedes cognitive impairment in this age group and that the association is related to physical health and perceptions of a lack of control.
目的
评估老年人在4年期间抑郁症状与认知功能之间的时间关联。
方法
采用纵向、交叉滞后、基于人群的设计，我们研究了896名年龄在70 - 97岁的社区居住成年人的抑郁症状和认知领域（包括处理速度、语言流畅性、面部和单词识别、情景记忆以及简单和选择反应时间）。
结果
交叉滞后结构方程模型表明，初始抑郁症状会影响随后的处理速度以及简单和选择反应时间，但随着时间推移，认知并不能预测抑郁症状。当模型针对感觉障碍、身体健康和控制点进行调整时，抑郁与认知变量之间的关联减弱。
结论
研究结果表明，在这个年龄组中，因果关系上抑郁先于认知障碍，并且这种关联与身体健康和缺乏控制感有关。
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